My steam project is about how the Zaire Ebola Virus EBOV Attacks The Immune System. I have used a wood stove as my abstract drawing. The Liver represents the wood stack. Where the wood stack filters out all the smoke and particulates caused by the fire. The Spleen represents the smoke filter/catalyst filter itself. When closed it forces the fire to burn the smoke, accumulating more energy from the smoke before it is ejected out of the smoke stack. It acts somewhat as a filter, as the smoke has to go through the catalyst before exiting through the smoke stack. The Lymph Nodes represent the catalyst handle. The handle opens and closes the catalyst. When closed the catalyst forces the fire to continue to burn the smoke before being filtered through the catalyst and out the chimney. When open the fire burns hotter and much quicker. This is less efficient. The Lymph nodes when activated weakens the body’s efficiency/strength. When the immune system/lymph nodes are not activated, the body works at normal efficiency. The window seal represents the epidermis, if the skin is broken, the EBOV is able to enter the body. If the seal of the window is broken, smoke is able to enter the house. The metal frame represents the blood vessels. The frame holds the fire inside, the life force of the wood stove. If the frame is exposed on any spot of the wood stove, smoke will enter the house, potentially killing the residents. If the blood vessels hemorrhage internally, you can die in a matter of minutes. The objectives that this project relate to are from Unit 5) The Muscle Tissues, Unit 6) The Nervous System, and Unit 3) All Main Types Of Tissues. My project is related to the muscle tissues by the various organs that are attacked by the EBOV. The project relates to the nervous system as the nerves, specifically the dendritic cells. The project relates to the main types of tissues, as connective, epithelial, and nervous tissue are directly affected by the EBOV. The Zaire Ebola Virus EBOV is the most common strain among humans, accounting for the greater majority of deaths across the world-(NLM Cell Death and Differentiation). The virus is transmitted through bodily fluids, direct contact of an infected person, and sexual transmission. EBOV enters the body through cuts of the superficial epidermal layer, mucous membranes, or through direct dissemination by bodily fluids. EBOV attacks the immune system by infecting the dendritic cells, monocytes, and macrophages. From this point on the EBOV targets the lymph nodes(Catalyst), resulting in swelling. The EBOV moves to strike the liver and spleen. This infection causes a strong inflammatory response. This is characterized by the massive release of chemokines and cytokines, the cytokines are proteins that signal anti inflammatory responses, while the chemokines contribute to the migration of the white blood cells. This massive immune response disrupts the regulation of the blood vessels. This results in Disseminated Intravascular Coagulation (DIC), and multiple organ dysfunction, which results in death. The DIC is characterized by the blood vessels clotting strongly in various sections of the blood vessels. This causes massive bleeding both internally and externally. This hemorrhagic event is what defines EBOV, where you bleed out of every orifice. DIC eventually leads to Hepatocellular Necrosis, which is the death of the liver tissue, specifically the hepatocytes. References
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