For my steam project I decorated a cake to compare a healthy individual’s cystic fibrosis transmembrane regulator ion channel (CFTR protein) with the CFTR protein of an individual that has a specific cftr gene mutation. This mutation causes one of the two gate domains to be closed. This restricts the flow of chloride ions, leading to the condition known as Cystic Fibrosis (CF). The mutated channel is shown on the right, with the extracellular gate domain being in a permanent closed conformation. On the opposing healthy channel, you can see that both the cytoplasmic domain and the extracellular domain are both in open conformations. This allows chloride ions (shown as brown coco puffs) to pass through the channel and move into and out of the cell. These chloride ions will serve to lighten mucus in healthy individuals, preventing the many complications of CF associated with thick sticky glue-like mucus. As these are both transmembrane proteins, they stretch across the phospholipid bilayer that makes up the cell membrane (illustrated by the two uncooked pasta noodles.).