This STEAM project explores the role of leukocytes (white blood cells, or WBCs) in the body’s inflammatory response, with a particular focus on granulocytes (neutrophils, eosinophils, and basophils). Leukocytes are crucial components of the immune system and are the only formed elements in blood that are complete cells, containing nuclei and organelles. The project examines the functions of these immune cells, especially how basophils contribute to the initiation and intensification of inflammation through the release of histamine.
Inflammation is a key defense mechanism that occurs in response to tissue damage or infection. It is typically characterized by redness, heat, swelling, pain, and occasionally loss of function. When injury occurs, mast cells detect cellular damage and release histamine, initiating the inflammatory process. This leads to increased blood flow and vascular permeability, allowing leukocytes such as neutrophils and basophils to migrate to the affected area. These cells work to neutralize pathogens and begin tissue repair.
The project also investigates diagnostic tools such as the Basophil Activation Test (BAT), which assesses the responsiveness of basophils to allergens. Research by Korošec et al. (2018) indicates that basophils are involved in allergic inflammation and are often present in higher numbers in skin diseases, asthma, and anaphylactic conditions. However, findings by Falcone et al. (2011) suggest limitations in the BAT test, as some individuals possess non-responsive basophils that do not react to IgE-mediated stimulation.
Through this investigation, the project aims to deepen understanding of how different types of leukocytes, particularly basophils, contribute to immune defense and the regulation of inflammation, offering insights into both normal and pathological immune responses.
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This STEAM project explores the role of leukocytes (white blood cells, or WBCs) in the body’s inflammatory response, with a particular focus on granulocytes (neutrophils, eosinophils, and basophils). Leukocytes are crucial components of the immune system and are the only formed elements in blood that are complete cells, containing nuclei and organelles. The project examines the functions of these immune cells, especially how basophils contribute to the initiation and intensification of inflammation through the release of histamine.
Inflammation is a key defense mechanism that occurs in response to tissue damage or infection. It is typically characterized by redness, heat, swelling, pain, and occasionally loss of function. When injury occurs, mast cells detect cellular damage and release histamine, initiating the inflammatory process. This leads to increased blood flow and vascular permeability, allowing leukocytes such as neutrophils and basophils to migrate to the affected area. These cells work to neutralize pathogens and begin tissue repair.
The project also investigates diagnostic tools such as the Basophil Activation Test (BAT), which assesses the responsiveness of basophils to allergens. Research by Korošec et al. (2018) indicates that basophils are involved in allergic inflammation and are often present in higher numbers in skin diseases, asthma, and anaphylactic conditions. However, findings by Falcone et al. (2011) suggest limitations in the BAT test, as some individuals possess non-responsive basophils that do not react to IgE-mediated stimulation.
Through this investigation, the project aims to deepen understanding of how different types of leukocytes, particularly basophils, contribute to immune defense and the regulation of inflammation, offering insights into both normal and pathological immune responses.