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  1. Multiple sclerosis (MS) is a complex and chronic autoimmune disorder that targets the central nervous system (CNS), comprising the brain and spinal cord. The disease is characterized by an immune-mediated attack on the myelin sheath, a protective layer surrounding neurons, leading to neural damage and disruption of routine signaling processes. While the precise cause of MS remains unknown, research highlights the interplay of genetic predisposition, environmental factors, infections such as the Epstein-Barr Virus, and low vitamin D levels as potential contributors. Competing theories propose that MS may originate externally, with antigens breaching the blood-brain barrier, or internally, through CNS abnormalities that trigger inflammation and tissue damage.

    MS manifests in various forms, including relapsing-remitting MS, secondary progressive MS, and benign MS, each differing in symptom severity and progression. Relapsing-remitting MS, the most common form, accounts for 70–80% of cases and features episodic inflammation with periods of remission. Other forms involve steady neurological decline or rapid disability progression, as seen in fulminant MS. Symptoms vary widely, often including cognitive decline, fatigue, bowel and bladder dysfunction, sexual dysfunction, anxiety, depression, and sleep disturbances, all influenced by the size and location of neural damage visible via MRI.

    Although MS has no cure, advancements in research are improving diagnostic precision and treatment options, with therapies focused on managing symptoms, reducing inflammation, and slowing disease progression. Exciting developments in remyelination science offer hope for restoring neural function and enhancing the quality of life for those affected by this challenging condition.

    Kira Furukawa

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